Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure
نویسندگان
چکیده
منابع مشابه
Acetaminophen attenuates rhabdomyolysis- induced renal failure
Release of myoglobin or hemoglobin into the circulation due to muscle injury or hemolysis can cause multiple problems, including renal failure. When these hemoproteins are released from the reducing environment of cells, the ferrous heme can be oxidized to the ferric state, conferring peroxidase activity to the hemoproteins. Consequently, hemoproteins can reduce hydroperoxides, such as hydrogen...
متن کاملAcute renal failure due to traumatic rhabdomyolysis.
Between 1990 and 1993, we studied 14 cases of acute renal failure due to prolonged muscular exercise (e.g., squat jumping, sit-ups) and blunt trauma inflicted by law enforcement personnel using sticks or leather belts. None of the patients had a prior history of myopathy, neuropathy, or renal disease. All were critically ill and required renal support in the form of dialysis. Although the morbi...
متن کاملExercise Induced Rhabdomyolysis with Compartment Syndrome and Renal Failure
Exertional rhabdomyolysis is sequela that is occasionally seen after strenuous exercise. The progression to compartment syndrome or renal failure is a rare complication that requires prompt recognition and treatment to prevent morbidity (Giannoglou et al. 2007). We present a case of a 22-year-old college football player who presented to the emergency department (ED) after a typical leg workout ...
متن کاملRhabdomyolysis and Acute Renal Failure after Gardening
Acute nontraumatic exertional rhabdomyolysis may arise when the energy supply to muscle is insufficient to meet demands, particularly in physically untrained individuals. We report on a psychiatric patient who developed large bruises and hemorrhagic blisters on both hands and arms, rhabdomyolysis of both forearm muscles with a moderate compartment syndrome, and consecutive acute renal failure f...
متن کاملAcute renal failure caused by nontraumatic rhabdomyolysis.
Nontraumatic rhabdomyolysis may be associated with severe metabolic disturbances. In particular, previous literature has described a 8-20% incidence of acute renal failure in rhabdomyolysis. The aim of this study was to evaluate our experience on 11 patients with acute renal failure treated by high-efficiency daily hemodialysis.
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2011
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2010.10.704